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2013 Meeting of the North Carolina Branch of the American Society for Microbiology

Program book:

Sponsors & Vendors (so far) :

East Carolina University

The American Society
for Microbiology

The NC Academy of Science



BioExpress

NC State University


When :

Saturday, October 26th, 2013

Where :

Howell Science Complex
East Carolina University
Greenville, NC 27834

The Howell Science Complex is on the ECU main campus, on the North side of East 10th Street between Founders Drive and College Hill Drive in Greenville.


Acommodations :

For those of you who will be traveling the day before the meeting, or staying the night afterwards, the following hotels are convenient :

  • Hilton Greenville, 207 Greenville Blvd SW, (252) 355-5000
  • Best Western Plus Suites, 2310 Greenville Blvd NE, (252) 752-2378
  • City Hotel & Bistro, 203 Greenville Blvd SW, (252) 355-8300
  • Wingate by Wyndham, 3212 S Memorial Dr, (252) 355-4283
  • Baymont Inn and Suites, 3439 S Memorial Dr, (252) 364-8980
  • Holiday Inn Express, 909 Moye Blvd, (252) 754-8300

Registration and abstract submission :

Register for the meeting by filling out and submitting the online registration/abstract form. Doing so will speed your meeting check-in (we'll have everything ready and waiting for you). The deadlne for abstract submission is has passed - no more abstracts can be accepted. The deadline for advance registration has also passed - you will need to register at the door.

Please verify your registration info - email Jim Brown with any corrections or other problems.

Payment :

The meeting registration and branch memerbship fee is $20. If you joined or renewed your NC Branch membership vis the ASM eStore (NOT the same as your ASM membership) this year, then the membership portion of this fee ($10) is waived. Registrants will receive a program (including abstracts and attendee roster), a box lunch and morning and afternoon refreshments.

The Registration and/or membership fee is payable at the door, the deadline for pre-payment has passed.

Information for presentors :

Information about timing will be posted here as soon as the schedule is worked out.

Short talks

We are scheduling 15 minutes for each talk. This includes Q&A and switching time, so plan on about 12 minutes for your talk, a couple of minutes for Q&A, leaving us 1 minute for switching to the next speaker.

Plan on bringing your presentation on a USB memory stick. If this isn't possible, let us know ASAP so we can arrange some other method to transfer your presentation.

Posters

Posters will be mounted using small paper clamps onto 36" x 48" hardboard sheets, which can be placed onto the easels either horizontally (landscape) or vertically (portrait). We will provide clamps, boards, and easels; all you need to bring is your poster. If your poster is in panels or pieces, you should let me (james_brown@ncsu.edu) know RIGHT AWAY so I can get styrofoam backing sheets so that you can pin your poster panels into place.

Schedule :

The day-long event will be a mix of short talks, the plenary and NC invited speakers, and poster presentations.

A detailed schedule will be posted before the meeting.

  • Registration will begin at 8:00AM
  • Sessions will begin at 9:00AM
  • The ASM Branch and NC Invitational lectures will begin at approximately 2:00PM
  • The meeting will adjourn at approximetly 4:30PM, followed by a business meeting

ASM Branch Lecture

Joseph A. Krzycki
THE Ohio State University

The 22nd amino acid : Pyrrolysine

As an NSF pre-doctoral fellow, Krzycki did seminal work on the major route found in nature for methane formation by microbes called methanogens. As a postdoc, he identified a methanogen DNA binding protein that was later found to be related to histone proteins that organize human genes. As a professor, he focused on understanding routes for methane formation from abundant methylated compounds found in natural environments. His lab has identified the proteins and genes essential for methane formation from five such substrates. They found some genes were interrupted by apparent "stop" signals, an observation which led to discovery of the 22nd genetically encoded amino acid, pyrrolysine. Pyrrolysine was recognized by Discover magazine as among the top discoveries of 2002. The Krzycki lab showed that methanogenesis from nitrogenous compounds required genetic code expansion to include pyrrolysine, and that this was mediated by as few as five genes. These five genes can reprogram the genetic code of E. coli to include pyrrolysine. Recently, the Krzycki lab described the complete route of pyrrolysine biosynthesis from the simpler amino acid, lysine. Dr. Krzycki has been named a Distinguished Scholar of the Ohio State University and is a member of the American Academy of Microbiology.

NC Invited Lecture

Jennifer Miller
NC State University

Borrelia burgdorferi and the innate immune system

My research focuses on the interaction between Borrelia burgdorferi and the innate immune system. My laboratory utilizes tissue culture and mouse models to examine both the bacterial and host-derived mechanisms driving the induction of Lyme arthritis. While a post-doc, I uncovered a novel and previously unappreciated role for Type I Interferon (IFN) in the development of severe Lyme arthritis within genetically susceptible inbred C3H mice by demonstrating that blockage of the Type I IFN receptor (IFNAR1) prior to B. burgdorferi-infection prevented the development of severe arthritis within the rear ankle joints of these mice. I also demonstrated that induction of IFN-profile genes did not depend upon B and T cell infiltration into joint tissue, as these genes were transcribed within the joints of infected C3H scid mice at levels equivalent to those seen in wild-type C3H mice. These data indicated that cells of the innate immune system govern induction of IFN-responsive gene transcripts within infected joint tissue. Utilizing murine bone marrow derived macrophages (BMDMs) as a model cell type, I discovered that B. burgdorferi-mediated induction of Type I IFN-responsive transcripts by these cells does not require TLRs 2,4, 9 or the adapter molecule MyD88. My laboratory is currently focused on the identification of B. burgdorferi ligands that trigger IFN-profile induction in macrophages, and the continued elucidation of innate immune components, and mechanistic pathways that drive both Type I IFN production and the development of Lyme arthritis. These studies will provide further insight into the mechanisms driving Lyme arthritis development, and lead to the development of improved theraupeutic interventions for Lyme disease patients.

Elections :

The meeting will be concluded by a brief business meeting, including the election of new officers. The nominees to date are:

  • President-elect (Currently Eric Anderson, ECU):


  • Secretary (currently Jim Brown, NCSU):
    • Jim has agreed to continue as Secretary

  • Treasurer (currently Wrennie Edwards, Novartis):
    • Wrennie has agreed to continue as Treasurer

  • Councilor (currently Ece Karatan, App State):
    • Ece Karatan has agreed to continue as Councilor

  • Alternate Councilor (currently Ed Swords, WFU)
    • Ed has agreed to continue as Alternate Councilor

If you would like to nominate someone or volunteer to run for office, please feel free to do so by email to Jim Brown.

Presentation Awards :

Web Links :

Organizing Committee :

Eric Anderson (President-elect)
Amy Grunden (President)
James W. Brown (Secretary)
Wrennie Edwards (Treasurer)
Ece Karatan (Councilor)

Contact :

Eric Anderson
Department of Biology
East Carolina University
N108 Howell Science Complex
Greenville, NC 27858
andersone@ecu.edu


Last updated July 28, 2015 by James W. Brown | Department of Biological Sciences | College of Sciences | NC State University